Understanding Letrozole: What Is It?

Letrozole is a medication commonly used in the treatment of certain types of breast cancer, particularly in postmenopausal women. It belongs to a class of drugs known as aromatase inhibitors, which work by decreasing the amount of estrogen the body makes. This reduction in estrogen can slow or stop the growth of hormone-sensitive tumors.

How Does Letrozole Work?

To grasp letrozole, what is its mechanism? It inhibits the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues. By blocking this enzyme, letrozole significantly lowers estrogen levels in the bloodstream. This is crucial because many breast cancers rely on estrogen to grow.

Indications for Use

Letrozole is primarily indicated for:

• Treatment of hormone receptor-positive breast cancer in postmenopausal women.
• Adjuvant therapy following surgery to reduce the risk of cancer recurrence.
• First-line therapy in advanced breast cancer cases where other treatments may not be suitable.

Dosage and Administration

The usual dose of letrozole Letrozol Teva 2.5mg is 2.5 mg taken once daily, with or without food. Treatment duration depends on individual response and specific medical guidelines. Patients are advised to follow their healthcare provider’s instructions carefully.

Side Effects

Like any medication, letrozole may cause side effects. Common ones include:

• Hot flashes
• Fatigue
• Nausea
• Joint pain

Serious side effects could include bone thinning (osteoporosis), liver issues, and increased cholesterol levels. Regular monitoring by healthcare providers is essential during treatment.

Conclusion

In summary, letrozole what is its significance? It plays a critical role in managing hormone-sensitive breast cancer, offering a therapeutic option that helps inhibit cancer progression. Understanding its function, dosage, and potential side effects allows patients and healthcare providers to make informed decisions regarding breast cancer treatment.